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How to test the sealing effectiveness of blister packaging
12/28/2013
Given the sound protectiveness, clear visual effect, convenient use and handiness, blister packaging has been widely applied to the solid medicine. To prevent the medicine from being affected by light, heat, oxygen and damp, and to keep the medicine from deterioration, the blister package should be excellent in terms of air-tightness. This has been clearly provided for in relevant national standards. The air-tightness refers to the reliability of blister packaging in terms of sealing. With this test, the effectiveness of sealing can be guaranteed.
Working principle: vacuum the vacuum chamber to create a differential pressure between the inside and outside of the sample which is immersed in water. Observe whether there is air leaking to the outside of the sample, or water infiltrating into the sample so as to determine the air-tightness of the package. Detailed steps are as follows:
Test equipment: sealed container which can withstand more than 1atm, to which the vacuum meter (accuracy degree: 2.5), the suction-pipe with valve connecting with the vacuum pump, the air pipe connecting with the atmosphere, and the water pipe connecting to the water source are installed. A pressing plate with its diameter shorter than that of the container should be placed inside the container.
Sampling: 100 blister cards are sampled and divided into 4 groups with 25 for each group.
Put the sample into the sealed container and fill in colored liquid. Make sure the liquid level is 25mm higher than the sample surface. Close the cover tightly and the vent valve. Start the vacuum pump to maintain the vacuum degree at 0.8MPa for 30 seconds. Then restore to the atmospheric pressure. Take the sample out and clean it with clean water. Wipe the sample and observe whether there is water infiltrating into the blister and the sealing layer.
